Note the singular 'Inquisition' - There was actually more than one inquisition.
The first was the Medieval Inquisition established in 1184 in France as a response to the Catharist heresy.
Then the Roman Inquisition, begun in 1542.
Separate again was the Spanish Inquisition commenced in 1478, a state institution used to identify conversos—Jews and Moors (Muslims) who pretended to convert to Christianity for purposes of gaining advantage in social circles but actually these 'converts' continued to practice there own faith.
Much confusion and controversy abounds, Stefano's wants to clear the myths and help straighten the record. I look forward to the finish programme coming to air.